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CS-W001157 4
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1-(6-Chloropyridin-3-yl)-N-methylmethanamine

  • CAS No. 120739-62-0

  • Cat. No. CS-0061790
  • Purity≥98%
  • MDL No.MFCD09802159

*For research and further manufacturing use only, not for direct human use.

1-(6-Chloropyridin-3-yl)-N-methylmethanamine|CS-0061790

Structure of 120739-62-0

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General Information

  • CAS No. 120739-62-0
  • Cat. No. CS-0061790
  • Purity ≥98%
  • MDL No. MFCD09802159
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₉ClN₂
  • Molecular Weight None
  • Synonym(s) N-[(6-chloropyridin-3-yl)methyl]-N-methylamine
  • SMILES CNCC1=CN=C(C=C1)Cl

Description

This pyridylamine derivative features a chlorinated pyridine core paired with a methylated amine side chain, enabling integration into bioactive molecule scaffolds. The electron-deficient pyridine ring enhances electrophilic reactivity, while the N-methyl group improves metabolic stability and membrane permeability. This compound serves as a key building block in medicinal chemistry for targeted drug discovery.

Application

1-(6-Chloropyridin-3-yl)-N-methylmethanamine serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the pyridine C6 position. Its tertiary amine functionality facilitates salt formation and improves solubility, while the chloropyridine moiety supports palladium-catalyzed cross-coupling reactions. The compound exhibits bench stability and compatibility with standard purification protocols, making it suitable for iterative synthesis of heterocyclic scaffolds and API intermediates.

Synthesis

  • Route1

    References

    • US5424437 A1, ;
  • Route2

    References

    • US5225423 A1, ;
  • Route3

    References

    • US5382671 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   24.92
  • LogP   1.4544
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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