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CS-W001157 4
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(1-Methyl-1H-indol-5-yl)methanamine

  • CAS No. 884507-17-9

  • Cat. No. CS-0113055
  • Molecule weight160.22
  • Purity≥97%
  • MDL No.MFCD09025839

*For research and further manufacturing use only, not for direct human use.

(1-Methyl-1H-indol-5-yl)methanamine|CS-0113055

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General Information

  • CAS No. 884507-17-9
  • Cat. No. CS-0113055
  • Purity ≥97%
  • MDL No. MFCD09025839
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₂N₂
  • Molecular Weight 160.22
  • Synonym(s) (1-METHYL-1H-INDOL-5-YL)METHYLAMINE
  • SMILES NCC1=CC2=C(N(C)C=C2)C=C1

Description

This indole derivative features a methylated nitrogen at the 1-position, enhancing solubility and metabolic stability. The pendant methanamine group provides a reactive handle for conjugation, enabling integration into bioactive molecules. Bench-stable under standard conditions, it serves as a key scaffold in medicinal chemistry for targeted ligand design.

Application

(1-Methyl-1H-indol-5-yl)methanamine serves as a versatile building block in medicinal chemistry, enabling the synthesis of indole-based scaffolds through standard amine functionalization. Its bench-stable nature and compatibility with common coupling reactions facilitate efficient access to biologically relevant derivatives. The methylated indole core provides enhanced metabolic stability and tunable polarity, making it valuable for drug discovery campaigns requiring optimized physicochemical properties.

Synthesis

  • Route1

    References

    • Journal of Medicinal Chemistry, , vol. 50, # 15 p. 3651 - 3660
  • Route2

    References

    • Journal of Medicinal Chemistry, , vol. 50, # 15 p. 3651 - 3660

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 3259
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H314
Precautionary Statements : P260-P264-P270-P280-P301+P330+P331-P304+P340-P363-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   30.95
  • LogP   1.637
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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