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CS-W001157 4
Total: USD 88.00

2,2-Difluorocyclopropan-1-amine hydrochloride

  • CAS No. 105614-25-3

  • Cat. No. CS-W000385
  • Purity≥95%
  • MDL No.MFCD07777150

*For research and further manufacturing use only, not for direct human use.

2,2-Difluorocyclopropan-1-amine hydrochloride|CS-W000385

Structure of 105614-25-3

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General Information

  • CAS No. 105614-25-3
  • Cat. No. CS-W000385
  • Purity ≥95%
  • MDL No. MFCD07777150
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₆ClF₂N
  • Molecular Weight 129.54
  • Synonym(s) 2,2-Difluorocyclopropylamine hydrochloride
  • SMILES NC1C(F)(F)C1.[H]Cl

Description

This bench-stable difluorocyclopropanamine hydrochloride features a strained cyclopropane ring bearing two fluorine atoms and a primary amine group, enabling direct incorporation into bioactive molecules. The trifluoromethyl-like electronic profile enhances metabolic stability while maintaining favorable binding interactions in target-directed synthesis.

Application

2,2-Difluorocyclopropan-1-amine hydrochloride serves as a stable, bench-ready building block for fluorinated heterocycles and bioactive molecule synthesis. Its strained cyclopropane core enables regioselective ring-opening reactions, while the amine functionality supports straightforward derivatization via alkylation, acylation, or coupling protocols. The difluoro substitution enhances metabolic stability and modulates electronic properties, making it valuable in medicinal chemistry workflows targeting CNS agents and kinase inhibitors.

Synthesis

  • Route1
    • null|null
      130340-08-8
    • ~85%
    • In-stock
      2,2-Difluorocyclopropan-1-amine hydrochloride|CS-W000385
      105614-25-3

    References

    • Journal of Fluorine Chemistry, , vol. 49, # 1 p. 127 - 139

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   0.7745
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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