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Structure of 637031-93-7
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3,3-difluorocyclobutanamine hydrochloride features a strained cyclobutane core with two fluorine atoms at the 3-position, conferring enhanced metabolic stability and lipophilicity. The amine moiety is protonated as the hydrochloride salt, ensuring high solubility and ease of handling. This scaffold integrates readily into bioactive molecules for medicinal chemistry applications.
3,3-Difluorocyclobutanamine hydrochloride serves as a valuable building block for fluorinated heterocycles in medicinal chemistry. The difluorocyclobutane core imparts metabolic stability and modulates lipophilicity, while the amine functionality enables straightforward derivatization via amidation, alkylation, or reductive amination. Its crystalline hydrochloride salt form ensures excellent bench stability, ease of handling, and compatibility with standard purification protocols, facilitating integration into multi-step synthetic sequences for drug discovery applications.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: