trans-3-Fluorocyclobutanamine hydrochloride

Name: trans-3-Fluorocyclobutanamine hydrochloride
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CAS No. 1408075-99-9
Cat. No. CS-0047786
Purity≥97%
MDL No.None

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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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trans-3-Fluorocyclobutanamine hydrochloride|CS-0047786

Structure of 1408075-99-9

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General Information

CAS No. 1408075-99-9
Cat. No. CS-0047786
Purity ≥97%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄H₉ClFN
Molecular Weight 125.57
Synonym(s) None
SMILES Cl.N[C@H]1C[C@H](F)C1

Description

trans-3-Fluorocyclobutanamine hydrochloride offers a rigid, conformationally constrained scaffold ideal for probing bioactive molecule geometry. The fluorinated cyclobutane ring imparts enhanced metabolic stability and modulates electronic properties, while the protonated amine ensures excellent solubility in aqueous systems. This bench-stable salt facilitates direct incorporation into peptide analogs and small-molecule libraries.

Application

trans-3-Fluorocyclobutanamine hydrochloride serves as a conformationally constrained, fluorinated amine building block for medicinal chemistry and peptide backbone modification. Its stability under standard synthetic conditions enables direct incorporation into bioactive scaffolds, while the trans-configuration enforces defined stereochemistry in cyclic systems. Functions as a versatile intermediate in the synthesis of fluorinated heterocycles and targeted small molecules.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

TPSA 26.02
LogP 0.8674
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Fatty ring compounds Cyclobutane compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

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trans-3-Fluorocyclobutanamine hydrochloride

CAS No. 1408075-99-9

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