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CS-W001157 4
Total: USD 88.00

3,3-Difluoroazetidine hydrochloride

  • CAS No. 288315-03-7

  • Cat. No. CS-W001214
  • Purity≥98%
  • MDL No.MFCD05663714

*For research and further manufacturing use only, not for direct human use.

3,3-Difluoroazetidine hydrochloride|CS-W001214

Structure of 288315-03-7

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General Information

  • CAS No. 288315-03-7
  • Cat. No. CS-W001214
  • Purity ≥98%
  • MDL No. MFCD05663714
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₆ClF₂N
  • Molecular Weight 129.54
  • Synonym(s) None
  • SMILES FC1(CNC1)F.Cl

Description

This bench-stable difluorinated azetidine scaffold integrates a strained three-membered ring with dual fluorine substituents, delivering enhanced metabolic stability and modulated basicity. The hydrochloride salt form improves solubility and handling, enabling efficient incorporation into bioactive molecules for medicinal chemistry applications.

Application

3,3-Difluoroazetidine (hydrochloride) serves as a conformationally constrained, bioisosteric building block for medicinal chemistry, enabling the introduction of enhanced metabolic stability and modulated polarity into drug candidates. The difluorinated azetidine ring exhibits robust bench stability, facilitates efficient coupling reactions, and functions effectively in standard amide bond formation and reductive amination protocols. Its compatibility with diverse functional groups and ease of purification make it a practical scaffold for constructing complex heterocyclic architectures in API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   0.6467
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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