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CS-W001157 4
Total: USD 88.00

(1R,2S)-2-Fluorocyclopropan-1-amine hydrochloride

  • CAS No. 141042-21-9

  • Cat. No. CS-0101187
  • Purity≥95%
  • MDL No.MFCD09258983

*For research and further manufacturing use only, not for direct human use.

(1R,2S)-2-Fluorocyclopropan-1-amine hydrochloride|CS-0101187

Structure of 141042-21-9

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General Information

  • CAS No. 141042-21-9
  • Cat. No. CS-0101187
  • Purity ≥95%
  • MDL No. MFCD09258983
  • Storage Store at room temperature, keep dry and cool
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₇ClFN
  • Molecular Weight 111.55
  • Synonym(s) cis-2-fluorocyclopropylaminetosylate
  • SMILES N[C@H]1[C@@H](F)C1.Cl

Description

This fluorinated cyclopropanamine derivative features a strained three-membered ring with stereocontrolled fluorine and amine substituents, enabling precise incorporation into bioactive scaffolds. The hydrochloride salt enhances solubility and stability under standard handling conditions, facilitating use in medicinal chemistry and synthetic methodology development.

Application

(1R,2S)-2-Fluorocyclopropan-1-amine hydrochloride serves as a valuable chiral building block in medicinal chemistry, enabling the synthesis of fluorinated cyclopropyl-containing scaffolds prevalent in bioactive molecules. Its bench-stable hydrochloride salt facilitates handling and purification, while the stereodefined fluorine and amine groups offer predictable reactivity in nucleophilic substitution, coupling, and cyclization processes. Functions effectively in standard synthetic workflows for drug discovery and process development.

Synthesis

  • Route1
    • null|null
      142977-51-3
    • ~88%
    • In-stock
      (1R,2S)-2-Fluorocyclopropan-1-amine hydrochloride|CS-0101187
      141042-21-9

    References

    • Tamura, Osamu; Hashimoto, Masaru; Kobayashi, Yuko; Katoh, Tadashi; Nakatani, Kazuhiko; et al. Tetrahedron Letters, 1992 , vol. 33, # 24 p. 3487 - 3490
  • Route2
    • rel-(1R,2S)-2-Fluorocyclopropan-1-amine 4-methylbenzenesulfonate|CS-0143344
      143062-73-1
    • ~%
    • In-stock
      (1R,2S)-2-Fluorocyclopropan-1-amine hydrochloride|CS-0101187
      141042-21-9

    References

    • Tamura, Osamu; Hashimoto, Masaru; Kobayashi, Yuko; Katoh, Tadashi; Nakatani, Kazuhiko; Kamada, Masahiro; Hayakawa, Isao; Akiba, Toshifumi; Terashima, Shiro Tetrahedron, 1994 , vol. 50, # 13 p. 3889 - 3904
  • Route3

    References

    • Tamura, Osamu; Hashimoto, Masaru; Kobayashi, Yuko; Katoh, Tadashi; Nakatani, Kazuhiko; Kamada, Masahiro; Hayakawa, Isao; Akiba, Toshifumi; Terashima, Shiro Tetrahedron, 1994 , vol. 50, # 13 p. 3889 - 3904

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   0.4773
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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