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2,2'-(Cyclopropane-1,1-diyl)bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolane)

  • CAS No. 2222867-16-3

  • Cat. No. CS-0495124
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2,2'-(Cyclopropane-1,1-diyl)bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolane)|CS-0495124

Structure of 2222867-16-3

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General Information

  • CAS No. 2222867-16-3
  • Cat. No. CS-0495124
  • Purity ≥95%
  • MDL No. None
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₅H₂₈B₂O₄
  • Molecular Weight 294.00
  • Synonym(s) None
  • SMILES CC1(C)C(C)(C)OB(O1)C2(CC2)B3OC(C)(C)C(C)(C)O3

Description

This cyclopropane-linked bisboronate ester delivers a stable, bench-ready platform for Suzuki-Miyaura cross-coupling reactions. The rigid cyclopropane spacer enhances structural integrity while the tetramethyl-substituted dioxaborolane moieties ensure high functional group tolerance and minimal protodeboronation.

Application

This boronate ester serves as a robust, bench-stable building block for Suzuki-Miyaura cross-coupling reactions. Its cyclopropane-linked bis(borane) architecture enables efficient homocoupling and sequential functionalization of biaryl scaffolds. The tetramethyl-substituted dioxaborolane moieties exhibit high stability, excellent functional group tolerance, and facilitate straightforward purification—ideal for constructing complex heterocyclic and pharmaceutical-relevant frameworks in iterative synthesis workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

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Computational Chemistry Data

  • TPSA   36.92
  • LogP   3.2442
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   2

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