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2,3-Dihydrobenzofuran-3-amine hydrochloride

  • CAS No. 860689-81-2

  • Cat. No. CS-0070832
  • Purity≥97%
  • MDL No.MFCD08544174

*For research and further manufacturing use only, not for direct human use.

2,3-Dihydrobenzofuran-3-amine hydrochloride|CS-0070832

Structure of 860689-81-2

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General Information

  • CAS No. 860689-81-2
  • Cat. No. CS-0070832
  • Purity ≥97%
  • MDL No. MFCD08544174
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₀ClNO
  • Molecular Weight 171.62
  • Synonym(s) 2,3-Dihydro-1-benzofuran-3-amine hydrochloride
  • SMILES NC1COC2=CC=CC=C12.[H]Cl

Description

2,3-Dihydrobenzofuran-3-amine hydrochloride offers a stable, moisture-tolerant platform for constructing bioactive heterocycles. The amine functionality enables direct coupling in peptide synthesis and medicinal chemistry scaffolds, while the fused ring system imparts rigidity and enhanced metabolic stability. This bench-stable salt facilitates handling and solubility in common organic solvents, streamlining incorporation into multi-step synthetic sequences.

Application

2,3-Dihydrobenzofuran-3-amine hydrochloride serves as a versatile scaffold for medicinal chemistry and heterocyclic synthesis, offering a stable, bench-ready platform for functional group derivatization. Its amine functionality enables direct incorporation into amide, urea, and sulfonamide linkages, while the dihydrobenzofuran core provides structural rigidity and favorable pharmacokinetic properties. The hydrochloride salt enhances solubility and handling, facilitating use in standard coupling reactions and parallel synthesis workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   1.5006
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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