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CS-W001157 4
Total: USD 88.00

5-Bromopyrazine-2-carboxylic acid

  • CAS No. 876161-05-6

  • Cat. No. CS-W018782
  • Purity≥97%
  • MDL No.MFCD09909672

*For research and further manufacturing use only, not for direct human use.

5-Bromopyrazine-2-carboxylic acid|CS-W018782

Structure of 876161-05-6

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General Information

  • CAS No. 876161-05-6
  • Cat. No. CS-W018782
  • Purity ≥97%
  • MDL No. MFCD09909672
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃BrN₂O₂
  • Molecular Weight 202.99
  • Synonym(s) 2-Bromopyrazine-5-carboxylic acid
  • SMILES BrC1=CN=C(C=N1)C(=O)O

Description

5-Bromopyrazine-2-carboxylic acid features a brominated pyrazine core with a carboxylic acid group at the 2-position, enabling direct coupling in cross-coupling reactions. This electron-deficient heterocycle integrates readily into pharmaceutical scaffolds and functional materials, offering enhanced reactivity and stability under standard conditions.

Application

5-Bromopyrazine-2-carboxylic acid serves as a versatile building block for heterocyclic synthesis, enabling palladium-catalyzed cross-coupling reactions due to its well-defined bromo and carboxylic acid functionalities. The molecule exhibits bench stability and facilitates efficient derivatization via amide formation or esterification, supporting applications in medicinal chemistry and API development. Its orthogonally reactive groups allow sequential functionalization in complex molecule assembly.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   63.08
  • LogP   0.9373
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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