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CS-W001157 4
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3-Bromo-2-pyrazinecarboxylic acid

  • CAS No. 937669-80-2

  • Cat. No. CS-W020213
  • Purity≥97%
  • MDL No.MFCD08753934

*For research and further manufacturing use only, not for direct human use.

3-Bromo-2-pyrazinecarboxylic acid|CS-W020213

Structure of 937669-80-2

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General Information

  • CAS No. 937669-80-2
  • Cat. No. CS-W020213
  • Purity ≥97%
  • MDL No. MFCD08753934
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃BrN₂O₂
  • Molecular Weight 202.99
  • Synonym(s) 3-Bromopyrazine-2-carboxylicacid
  • SMILES OC(C1=NC=CN=C1Br)=O

Description

3-Bromo-2-pyrazinecarboxylic acid is a heterocyclic building block featuring a brominated pyrazine core paired with a carboxylic acid group. This combination enables direct functionalization in cross-coupling reactions and facilitates conjugation to biomolecules or polymer backbones. The electron-deficient pyrazine ring enhances reactivity in palladium-catalyzed transformations, while the carboxylic acid offers versatile derivatization potential under standard conditions.

Application

3-Bromo-2-pyrazinecarboxylic acid serves as a versatile building block for heterocyclic synthesis, enabling direct functionalization at the pyrazine core. Its bromo group facilitates palladium-catalyzed cross-coupling reactions, while the carboxylic acid moiety supports derivatization via amide formation or esterification. The compound exhibits good bench stability and is compatible with standard purification techniques, making it well-suited for medicinal chemistry campaigns and API intermediate development.

Synthesis

  • Route1

    References

    • Journal of Medicinal Chemistry, , vol. 55, # 23 p. 10475 - 10489
  • Route2

    References

    • Journal of Medicinal Chemistry, , vol. 55, # 23 p. 10475 - 10489
  • Route3

    References

    • Journal of Medicinal Chemistry, , vol. 55, # 23 p. 10475 - 10489

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   63.08
  • LogP   0.9373
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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