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CS-W001157 4
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Methyl 5-bromopyrazine-2-carboxylate

  • CAS No. 210037-58-4

  • Cat. No. CS-W019731
  • Purity≥97%
  • MDL No.MFCD09991715

*For research and further manufacturing use only, not for direct human use.

Methyl 5-bromopyrazine-2-carboxylate|CS-W019731

Structure of 210037-58-4

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General Information

  • CAS No. 210037-58-4
  • Cat. No. CS-W019731
  • Purity ≥97%
  • MDL No. MFCD09991715
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅BrN₂O₂
  • Molecular Weight 217.02
  • Synonym(s) Methyl 5-bromopyrazine-2-carboxylate; Pyrazinecarboxylicacid, 5-bromo-, methyl ester (9CI)
  • SMILES O=C(C1=NC=C(Br)N=C1)OC

Description

Methyl 5-bromopyrazine-2-carboxylate features a pyrazine core bearing bromo and ester functionalities, enabling direct incorporation into cross-coupling reactions. The electron-deficient heterocycle facilitates palladium-catalyzed transformations, while the methyl ester group offers convenient downstream derivatization. This bench-stable reagent delivers efficient access to complex nitrogen-containing architectures.

Application

Methyl 5-bromopyrazine-2-carboxylate serves as a versatile building block in heterocyclic synthesis, enabling palladium-catalyzed cross-coupling reactions due to its well-established bromo group reactivity. The methyl ester functionality offers compatibility with standard hydrolysis and derivatization protocols. Its stability under ambient conditions and ease of purification make it suitable for iterative synthetic strategies in medicinal chemistry and materials science applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   52.08
  • LogP   1.0257
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   1

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