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CS-W001157 4
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Methyl 6-bromopyrazine-2-carboxylate

  • CAS No. 40155-34-8

  • Cat. No. CS-W018602
  • Purity≥98%
  • MDL No.MFCD14155890

*For research and further manufacturing use only, not for direct human use.

Methyl 6-bromopyrazine-2-carboxylate|CS-W018602

Structure of 40155-34-8

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General Information

  • CAS No. 40155-34-8
  • Cat. No. CS-W018602
  • Purity ≥98%
  • MDL No. MFCD14155890
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅BrN₂O₂
  • Molecular Weight 217.02
  • Synonym(s) Methyl-6-bromopyrazine-2-carboxylate
  • SMILES O=C(C1=NC(Br)=CN=C1)OC

Description

Methyl 6-bromopyrazine-2-carboxylate features a brominated pyrazine core with a methyl ester at the C2 position, enabling direct functionalization in cross-coupling reactions. The electron-deficient heterocycle facilitates palladium-catalyzed transformations, while the ester group offers synthetic versatility for downstream derivatization. This bench-stable reagent integrates efficiently into complex molecular architectures.

Application

Methyl 6-bromopyrazine-2-carboxylate serves as a versatile building block in heterocyclic synthesis, enabling palladium-catalyzed cross-coupling reactions due to its well-defined bromine handle. The pyrazine core provides a rigid, electron-deficient scaffold ideal for constructing pharmaceutical intermediates. Its bench-stable nature and compatibility with standard reaction conditions facilitate efficient functionalization and purification in medicinal chemistry workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   52.08
  • LogP   1.0257
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   1

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