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CS-W001157 4
Total: USD 88.00

2-Bromo-5-fluoro-6-methylpyridine

  • CAS No. 374633-38-2

  • Cat. No. CS-W008966
  • Purity≥96%
  • MDL No.MFCD03095064

*For research and further manufacturing use only, not for direct human use.

2-Bromo-5-fluoro-6-methylpyridine|CS-W008966

Structure of 374633-38-2

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General Information

  • CAS No. 374633-38-2
  • Cat. No. CS-W008966
  • Purity ≥96%
  • MDL No. MFCD03095064
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅BrFN
  • Molecular Weight 190.01
  • Synonym(s) 6-Bromo-3-fluoropicoline
  • SMILES CC1=NC(Br)=CC=C1F

Description

2-Bromo-5-fluoro-6-methylpyridine features a sterically accessible pyridine core functionalized with bromo, fluoro, and methyl groups at adjacent positions. This electron-deficient heterocycle serves as a key building block in medicinal chemistry, enabling direct coupling reactions under standard conditions. The strategic substitution pattern facilitates rapid diversification in drug discovery workflows.

Application

2-Bromo-5-fluoro-6-methylpyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its complementary halogen and fluorine substituents. The methyl group enhances regiochemical control in cyclization sequences, while the bromo and fluoro functionalities offer orthogonal reactivity for sequential functionalization. Bench-stable and amenable to standard purification techniques, it facilitates efficient access to substituted pyridine scaffolds relevant to pharmaceutical development.

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.29162
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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