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CS-W001157 4
Total: USD 88.00

6-Bromo-2-(difluoromethyl)-3-fluoropyridine

  • CAS No. 1806763-56-3

  • Cat. No. CS-0163548
  • Purity≥97%
  • MDL No.MFCD25477698

*For research and further manufacturing use only, not for direct human use.

6-Bromo-2-(difluoromethyl)-3-fluoropyridine|CS-0163548

Structure of 1806763-56-3

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General Information

  • CAS No. 1806763-56-3
  • Cat. No. CS-0163548
  • Purity ≥97%
  • MDL No. MFCD25477698
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃BrF₃N
  • Molecular Weight 225.99
  • Synonym(s) None
  • SMILES FC1=CC=C(Br)N=C1C(F)F

Description

6-Bromo-2-(difluoromethyl)-3-fluoropyridine features a strategically positioned difluoromethyl group that enhances metabolic stability and modulates electronic properties. This fluorinated pyridine scaffold integrates readily into medicinal chemistry workflows, offering improved lipophilicity and bioavailability. The bromo substituent enables facile cross-coupling transformations under standard conditions.

Application

6-Bromo-2-(difluoromethyl)-3-fluoropyridine serves as a versatile building block in medicinal chemistry, enabling direct incorporation of fluorinated and brominated motifs into bioactive scaffolds. Its ortho-bromine and trifluoromethyl-like difluoromethyl group facilitate palladium-catalyzed cross-coupling reactions and offer enhanced metabolic stability. The molecule exhibits excellent bench stability and compatibility with standard synthetic protocols, making it ideal for the construction of complex heterocycles and API candidates requiring precise fluorination patterns.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.9208
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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