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CS-W001157 4
Total: USD 88.00

5,6,7,8-Tetrahydronaphthalen-1-ol

  • CAS No. 529-35-1

  • Cat. No. CS-0132457
  • Purity≥98%
  • MDL No.MFCD00001734

*For research and further manufacturing use only, not for direct human use.

5,6,7,8-Tetrahydronaphthalen-1-ol|CS-0132457

Structure of 529-35-1

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General Information

  • CAS No. 529-35-1
  • Cat. No. CS-0132457
  • Purity ≥98%
  • MDL No. MFCD00001734
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₂O
  • Molecular Weight 148.20
  • Synonym(s) 5,6,7,8-Tetrahydro-1-naphthol
  • SMILES OC1=C2CCCCC2=CC=C1

Description

This bench-stable phenolic compound features a fused bicyclic structure with a hydroxyl group at the 1-position, enabling direct incorporation into synthetic routes requiring a rigid, electron-rich aromatic scaffold. The tetrahydronaphthalene core offers enhanced solubility and reduced volatility compared to unsubstituted naphthalene derivatives, facilitating handling in multi-step organic transformations.

Application

5,6,7,8-Tetrahydronaphthalen-1-ol serves as a versatile synthetic intermediate featuring a benzylic alcohol within a partially saturated naphthalene framework. Its stability under standard reaction conditions enables reliable functionalization via oxidation, protection, or coupling reactions. The molecule functions as a key building block in the synthesis of bioactive heterocycles and pharmaceutical scaffolds, offering predictable reactivity and compatibility with common protecting group strategies.

Synthesis

  • Route1
    • 1-Naphthol Duloxetine Impurity|CS-0213938
      90-15-3
    • ~93%
    • In-stock
      5,6,7,8-Tetrahydronaphthalen-1-ol|CS-0132457
      529-35-1

    References

    • Tsukinoki, Takehito; Kanda, Tadashige; Liu, Guo-Bin; Tsuzuki, Hirohisa; Tashiro, Masashi Tetrahedron Letters, 2000 , vol. 41, # 31 p. 5865 - 5868
  • Route2
    • null|null
      21336-06-1
    • ~74%
    • In-stock
      5,6,7,8-Tetrahydronaphthalen-1-ol|CS-0132457
      529-35-1

    References

    • Odedra, Arjan; Wu, Chang-Jung; Pratap, Taduri Bhanu; Huang, Chun-Wei; Ran, Ying-Fen; Liu, Rai-Shung Journal of the American Chemical Society, 2005 , vol. 127, # 10 p. 3406 - 3412
  • Route3

    References

    • EP1637512 A1, ; Page/Page column 12 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   2.271
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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