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CS-W001157 4
Total: USD 88.00

NH2-PEG3-C2-NH-Boc

  • CAS No. 101187-40-0

  • Cat. No. CS-0032897
  • Purity≥97%
  • MDL No.MFCD16619220

*For research and further manufacturing use only, not for direct human use.

NH2-PEG3-C2-NH-Boc|CS-0032897

Structure of 101187-40-0

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General Information

  • CAS No. 101187-40-0
  • Cat. No. CS-0032897
  • Purity ≥97%
  • MDL No. MFCD16619220
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₂₈N₂O₅
  • Molecular Weight 292.37
  • Synonym(s) PROTAC Linker 15
  • SMILES NCCOCCOCCOCCNC(OC(C)(C)C)=O

Description

NH2-PEG3-C2-NH-Boc features a triethylene glycol spacer flanked by amine and carbamate functionalities, enabling efficient conjugation and protection strategies in peptide synthesis. This bifunctional reagent combines solubility and stability, facilitating modular assembly of complex biomolecules under standard conditions.

Application

NH2-PEG3-C2-NH-Boc serves as a versatile bifunctional linker for peptide and conjugate synthesis, combining the solubility of triethylene glycol (PEG3) with orthogonal protection via the Boc group. The primary amine enables efficient coupling reactions, while the C2 spacer provides optimal distance for bioconjugation applications. This reagent exhibits excellent bench stability, facilitates purification by standard chromatography, and functions reliably in solid-phase and solution-phase workflows.

Synthesis

  • Route1
    • H2N-PEG4-NH2 HQ|CS-1347222
      929-75-9
    • In-stock
      Di-tert-butyl dicarbonate|CS-0017817
      24424-99-5
    • ~97%
    • In-stock
      NH2-PEG3-C2-NH-Boc|CS-0032897
      101187-40-0

    References

    • Tetrahedron, , vol. 68, # 52 p. 10818 - 10826
  • Route2
    • H2N-PEG4-NH2 HQ|CS-1347222
      929-75-9
    • null|null
      1538-75-6
    • ~32%
    • In-stock
      NH2-PEG3-C2-NH-Boc|CS-0032897
      101187-40-0

    References

    • WO2005/30258 A2, ; Page/Page column 115 ; WO 2005/030258 A2
  • Route3

    References

    • Journal of the American Chemical Society, , vol. 134, # 1 p. 83 - 86

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   92.04
  • LogP   0.5196
  • H_Acceptors   6
  • H_Donors   2
  • Rotatable_Bonds   11

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