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CS-W001157 4
Total: USD 88.00

2-Bromo-3-fluoro-6-methylpyridine

  • CAS No. 374633-36-0

  • Cat. No. CS-W019922
  • Purity≥98%
  • MDL No.MFCD03095061

*For research and further manufacturing use only, not for direct human use.

2-Bromo-3-fluoro-6-methylpyridine|CS-W019922

Structure of 374633-36-0

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General Information

  • CAS No. 374633-36-0
  • Cat. No. CS-W019922
  • Purity ≥98%
  • MDL No. MFCD03095061
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅BrFN
  • Molecular Weight 190.01
  • Synonym(s) 2-Brom-3-fluor-6-methylpyridin
  • SMILES CC1=CC=C(F)C(Br)=N1

Description

2-Bromo-3-fluoro-6-methylpyridine is a halogenated pyridine derivative featuring complementary electrophilic and nucleophilic handles. The bromo group enables palladium-catalyzed coupling reactions, while the fluorine atom offers enhanced metabolic stability and electronic tuning. This scaffold integrates readily into bioactive molecules and serves as a key intermediate in medicinal chemistry and agrochemical development.

Application

2-Bromo-3-fluoro-6-methylpyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its complementary halogen reactivity. The fluorine and methyl groups provide orthogonal functionalization sites, while the pyridine core offers favorable electronic properties for downstream derivatization. Bench-stable and amenable to standard purification methods, it facilitates efficient synthesis of complex heterocyclic scaffolds relevant to pharmaceutical development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.29162
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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