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CS-W001157 4
Total: USD 88.00

Propargyl-PEG4-Tos

  • CAS No. 875770-32-4

  • Cat. No. CS-0107583
  • Purity≥95%
  • MDL No.MFCD28950765

*For research and further manufacturing use only, not for direct human use.

Propargyl-PEG4-Tos|CS-0107583

Structure of 875770-32-4

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General Information

  • CAS No. 875770-32-4
  • Cat. No. CS-0107583
  • Purity ≥95%
  • MDL No. MFCD28950765
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₈H₂₆O₇S
  • Molecular Weight 386.46
  • Synonym(s) None
  • SMILES C#CCOCCOCCOCCOCCOS(C1=CC=C(C)C=C1)(=O)=O

Description

Propargyl-PEG4-Tos features a propargyl group linked via a four-ethylene glycol unit to a p-toluenesulfonyl (Tos) leaving group. This bifunctional reagent enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) and facilitates conjugation in bioorthogonal labeling workflows. The PEG spacer provides enhanced solubility and reduced aggregation in aqueous environments.

Application

Propargyl-PEG4-Tos serves as a versatile bifunctional linker for conjugation and polymer chemistry, enabling efficient CuAAC click reactions via its terminal alkyne group. The PEG4 spacer provides enhanced solubility and reduced aggregation, while the tosyl leaving group facilitates nucleophilic substitution under mild conditions. This compound functions reliably in modular synthesis of bioconjugates, functionalized polymers, and surface-tethered molecules with predictable reactivity and excellent bench stability.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362

Quality Control

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Computational Chemistry Data

  • TPSA   80.29
  • LogP   1.39992
  • H_Acceptors   7
  • H_Donors   0
  • Rotatable_Bonds   15

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