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CS-W001157 4
Total: USD 88.00

Propargyl-PEG2-Tos

  • CAS No. 145916-41-2

  • Cat. No. CS-0114887
  • Purity≥98%
  • MDL No.MFCD29764327

*For research and further manufacturing use only, not for direct human use.

Propargyl-PEG2-Tos|CS-0114887

Structure of 145916-41-2

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General Information

  • CAS No. 145916-41-2
  • Cat. No. CS-0114887
  • Purity ≥98%
  • MDL No. MFCD29764327
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₄O₄S
  • Molecular Weight 254.30
  • Synonym(s) None
  • SMILES C#CCOCCOS(C1=CC=C(C)C=C1)(=O)=O

Description

Propargyl-PEG2-Tos features a propargyl group flanked by a short PEG spacer and a tosyl leaving group, enabling efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions. This bifunctional scaffold integrates seamlessly into bioconjugation workflows, offering enhanced solubility and controlled reactivity for site-specific labeling.

Application

Propargyl-PEG2-Tos serves as a versatile bifunctional linker for conjugation and synthesis, combining a reactive terminal alkyne with a stable, hydrophilic PEG2 spacer and a tosyl leaving group. It enables efficient CuAAC click chemistry while allowing orthogonal deprotection under mild conditions, facilitating modular assembly of complex molecules. Its bench-stable nature and compatibility with diverse functional groups make it ideal for peptide modification, probe synthesis, and the construction of bioconjugates and API intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   52.6
  • LogP   1.35012
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   6

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