Tos-PEG2-OH

Name: Tos-PEG2-OH
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 118591-58-5
Cat. No. CS-0133776
Purity≥95%
MDL No.MFCD22574797

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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Structure of 118591-58-5

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General Information

CAS No. 118591-58-5
Cat. No. CS-0133776
Purity ≥95%
MDL No. MFCD22574797
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₁H₁₆O₅S
Molecular Weight 260.31
Synonym(s) None
SMILES OCCOCCOS(C1=CC=C(C)C=C1)(=O)=O

Description

Tos-PEG2-OH is a bench-stable, moisture-tolerant PEG-based linker featuring a tosyl (Tos) group at one end and a terminal hydroxyl for conjugation. This dual-functional architecture enables efficient coupling in bioconjugation workflows, particularly where orthogonal reactivity or controlled release is required. The short PEG spacer provides enhanced solubility without compromising stability.

Application

Tos-PEG2-OH serves as a versatile bifunctional building block for the synthesis of PEGylated compounds, enabling efficient conjugation via its tosylate group while retaining a reactive hydroxyl terminus. Its bench-stable nature and excellent solubility in common organic solvents facilitate straightforward purification and compatibility with diverse reaction conditions. Widely employed in peptide modification and drug delivery systems, it supports precise control over molecular weight and functionalization in biopharmaceutical applications.

Synthesis

Route1
- 98-59-9
- In-stock
  
  111-46-6
- ~97%
- In-stock
  
  118591-58-5
References
- NATIONAL UNIVERSITY OF IRELAND, GALWAY Patent: US2011/217750 A1, 2011 ; Location in patent: Page/Page column 19 ;
Route2
- In-stock
  
  111-77-3
- 98-59-9
- ~%
- In-stock
  
  118591-58-5
References
- Song, Rita; Kim, Yeong-Sang; Lee, Chong Ock; Sohn, Youn Soo Tetrahedron Letters, 2003 , vol. 44, # 8 p. 1537 - 1540

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 72.83
LogP 0.70922
H_Acceptors 5
H_Donors 1
Rotatable_Bonds 7

Other Classifications

Life Science Linker Hydroxy PEG

Life Science Linker PEG Tosylate

Building Blocks Functional Group Alcohol

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Chemical Biology PEGylation Monofunctional PEG and Oligoethylene Glycols

Chemical Biology PEGylation Heterobifunctional PEG and Oligoethylene Glycols

Chemical Biology PEGylation PEG Oligomers

Biochemistry Biochemicals and Reagents Bioconjugation PEGylation Reagents and PEG Spacers

Key Words

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Tos-PEG2-OH

CAS No. 118591-58-5

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