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CS-W001157 4
Total: USD 88.00

m-PEG2-Tos

  • CAS No. 50586-80-6

  • Cat. No. CS-0031175
  • Purity≥96%
  • MDL No.MFCD13184964

*For research and further manufacturing use only, not for direct human use.

m-PEG2-Tos|CS-0031175

Structure of 50586-80-6

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General Information

  • CAS No. 50586-80-6
  • Cat. No. CS-0031175
  • Purity ≥96%
  • MDL No. MFCD13184964
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₈O₅S
  • Molecular Weight None
  • Synonym(s) None
  • SMILES COCCOCCOS(C1=CC=C(C)C=C1)(=O)=O

Description

m-PEG2-Tos features a para-toluensulfonate leaving group flanked by a short ethylene glycol spacer, enabling efficient conjugation in bioorthogonal workflows. This bench-stable derivative facilitates rapid coupling with nucleophiles under mild conditions, delivering clean reaction profiles and high yields.

Application

m-PEG2-Tos serves as a versatile bifunctional linker for conjugation and solid-phase synthesis, combining the solubility and stability of a short PEG spacer with a readily cleavable tosyl leaving group. It facilitates efficient amine functionalization and enables clean deprotection under mild conditions, making it ideal for peptide, oligonucleotide, and small-molecule derivatization workflows.

Synthesis

  • Route1
    • In-stock
      Methyl-PEG2-alcohol|CS-W013578
      111-77-3
    • null|null
      98-59-9
    • ~99%
    • In-stock
      m-PEG2-Tos|CS-0031175
      50586-80-6

    References

    • Harjani, Jitendra R.; Liang, Chen; Jessop, Philip G. Journal of Organic Chemistry, 2011 , vol. 76, # 6 p. 1683 - 1691
  • Route2
    • In-stock
      m-PEG3-OH|CS-0114074
      112-35-6
    • null|null
      98-59-9
    • ~10%
    • In-stock
      m-PEG2-Tos|CS-0031175
      50586-80-6

    References

    • Hao, Jing; Servello, John; Sista, Prakash; Biewer, Michael C.; Stefan, Mihaela C. Journal of Materials Chemistry, 2011 , vol. 21, # 29 p. 10623 - 10628
  • Route3
    • null|null
      71776-35-7
    • null|null
      98-59-9
    • ~%
    • In-stock
      m-PEG2-Tos|CS-0031175
      50586-80-6

    References

    • Chao,Y. et al. Journal of the American Chemical Society, 1979 , vol. 101, # 17 p. 4948 - 4958

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P301+P310-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   61.83
  • LogP   1.36332
  • H_Acceptors   5
  • H_Donors   0
  • Rotatable_Bonds   8

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