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CS-W001157 4
Total: USD 88.00

Tetraethylene glycol monotosylate

  • CAS No. 77544-60-6

  • Cat. No. CS-0017887
  • Purity≥95%
  • MDL No.MFCD22056303

*For research and further manufacturing use only, not for direct human use.

Tetraethylene glycol monotosylate|CS-0017887

Structure of 77544-60-6

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General Information

  • CAS No. 77544-60-6
  • Cat. No. CS-0017887
  • Purity ≥95%
  • MDL No. MFCD22056303
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₅H₂₄O₇S
  • Molecular Weight 348.41
  • Synonym(s) Tos-PEG4
  • SMILES OCCOCCOCCOCCOS(C1=CC=C(C)C=C1)(=O)=O

Description

Tetraethylene glycol monotosylate serves as a stable, moisture-tolerant etherifying agent, enabling efficient O-alkylation under standard conditions. The tosylate moiety provides a high leaving group ability, facilitating nucleophilic substitution with alcohols, thiols, and amines. This reagent integrates seamlessly into synthetic workflows requiring selective ether formation.

Synthesis

  • Route1
    • HO-PEG4-OH HQ|CS-1347183
      112-60-7
    • null|null
      98-59-9
    • ~98%
    • In-stock
      Tetraethylene glycol monotosylate|CS-0017887
      77544-60-6

    References

    • Park, Ki Duk; Liu, Rihe; Kohn, Harold Chemistry and Biology, 2009 , vol. 16, # 7 p. 763 - 772
  • Route2
    • HO-PEG4-OH HQ|CS-1347183
      112-60-7
    • null|null
      98-59-9
    • ~85%
    • In-stock
      Bis-Tos-PEG4|CS-W004816
      37860-51-8
    • In-stock
      Tetraethylene glycol monotosylate|CS-0017887
      77544-60-6

    References

    • Organic Letters, , vol. 4, # 14 p. 2329 - 2332
  • Route3
    • HO-PEG4-OH HQ|CS-1347183
      112-60-7
    • null|null
      104-15-4
    • ~81%
    • In-stock
      Tetraethylene glycol monotosylate|CS-0017887
      77544-60-6

    References

    • Percec, Virgil; Leowanawat, Pawaret; Sun, Hao-Jan; Kulikov, Oleg; Nusbaum, Christopher D.; Tran, Tam M.; Bertin, Annabelle; Wilson, Daniela A.; Peterca, Mihai; Zhang, Shaodong; Kamat, Neha P.; Vargo, Kevin; Moock, Diana; Johnston, Eric D.; Hammer, Daniel A.; Pochan, Darrin J.; Chen, Yingchao; Chabre, Yoann M.; Shiao, Tze C.; Bergeron-Brlek, Milan; Andre, Sabine; Roy, Rene; Gabius, Hans-J.; Heiney, Paul A. Journal of the American Chemical Society, 2013 , vol. 135, # 24 p. 9055 - 9077

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS06
Signal Word : Danger
UN#: 2927
Class : 6.1 (8)
Packing Group : Ⅱ
Hazard Statements : H301-H314
Precautionary Statements : P260-P264-P270-P280-P301+P330+P331-P304+P340-P330-P363-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   91.29
  • LogP   0.74242
  • H_Acceptors   7
  • H_Donors   1
  • Rotatable_Bonds   13

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