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CS-W001157 4
Total: USD 88.00

6-Cyclopropylpyridin-2-amine

  • CAS No. 857292-66-1

  • Cat. No. CS-0239998
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

6-Cyclopropylpyridin-2-amine|CS-0239998

Structure of 857292-66-1

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General Information

  • CAS No. 857292-66-1
  • Cat. No. CS-0239998
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₀N₂
  • Molecular Weight 134.18
  • Synonym(s) None
  • SMILES C1=CC(=NC(=C1)N)C2CC2

Description

6-Cyclopropylpyridin-2-amine features a cyclopropyl group at the 6-position of pyridin-2-amine, enhancing lipophilicity and metabolic stability. This scaffold integrates readily into kinase inhibitors and bioactive molecules, offering improved membrane permeability and target engagement in medicinal chemistry applications.

Application

6-Cyclopropylpyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling reactions. Its pyridine nitrogen and primary amine functionality offer orthogonal reactivity for sequential derivatization. The cyclopropyl group enhances metabolic stability and modulates electronic properties, contributing to favorable pharmacokinetic profiles. Bench-stable and readily purified by chromatography, it functions effectively in Suzuki-Miyaura, Buchwald-Hartwig, and amide coupling protocols, supporting efficient synthesis of target molecules.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.5412
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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