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CS-W001157 4
Total: USD 88.00

2-Cyclopropylpyridin-4-amine

  • CAS No. 340006-71-5

  • Cat. No. CS-0316152
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Cyclopropylpyridin-4-amine|CS-0316152

Structure of 340006-71-5

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General Information

  • CAS No. 340006-71-5
  • Cat. No. CS-0316152
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₀N₂
  • Molecular Weight 134.18
  • Synonym(s) 4-Pyridinamine,2-cyclopropyl-(9CI)
  • SMILES C1CC1C2=NC=CC(=C2)N

Description

2-Cyclopropylpyridin-4-amine features a pyridine core with a cyclopropyl group at the 2-position and an amino substituent at the 4-position, delivering enhanced metabolic stability and improved solubility. This scaffold integrates readily into kinase inhibitors and bioactive molecules, offering favorable binding affinity in target-directed drug discovery.

Application

2-Cyclopropylpyridin-4-amine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling reactions. Its pyridine core offers favorable electronic properties and metabolic stability, while the cyclopropyl group enhances lipophilicity and conformational rigidity. The primary amine facilitates facile derivatization via acylation, alkylation, or transition-metal-catalyzed cross-coupling, supporting rapid SAR exploration. Bench-stable and readily purified by chromatography or recrystallization, it functions effectively in both small-molecule synthesis and API development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.5412
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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