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CS-W001157 4
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6-Cyclopropylpyridin-3-amine

  • CAS No. 1159821-66-5

  • Cat. No. CS-W006338
  • Purity≥95%
  • MDL No.MFCD12033370

*For research and further manufacturing use only, not for direct human use.

6-Cyclopropylpyridin-3-amine|CS-W006338

Structure of 1159821-66-5

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General Information

  • CAS No. 1159821-66-5
  • Cat. No. CS-W006338
  • Purity ≥95%
  • MDL No. MFCD12033370
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₀N₂
  • Molecular Weight 134.18
  • Synonym(s) 6-Cyclopropyl-3-pyridinamine
  • SMILES NC1=CC=C(C2CC2)N=C1

Description

6-Cyclopropylpyridin-3-amine features a pyridine core functionalized with a cyclopropyl group at the 6-position and a primary amine at the 3-position. This configuration imparts enhanced lipophilicity and metabolic stability, making it a valuable scaffold in medicinal chemistry for kinase inhibitors and CNS-targeted therapeutics. The cyclic amine moiety enables hydrogen bonding and coordination in biological binding pockets.

Application

6-Cyclopropylpyridin-3-amine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling reactions. Its pyridine core offers favorable electronic properties for metal-catalyzed transformations, while the cyclopropyl group provides steric modulation and metabolic stability. The primary amine facilitates rapid derivatization, and the compound exhibits excellent bench stability and ease of purification, making it well-suited for high-throughput synthesis and process development workflows.

Synthesis

  • Route1
    • 2-Cyclopropyl-5-nitropyridine|CS-0215457
      1190380-55-2
    • ~11%
    • In-stock
      6-Cyclopropylpyridin-3-amine|CS-W006338
      1159821-66-5

    References

    • MEDICAL RESEARCH COUNCIL Patent: WO2009/122180 A1, 2009 ; Location in patent: Page/Page column 115 ; WO 2009/122180 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.5412
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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