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CS-W001157 4
Total: USD 88.00

6-Cyclopropylnicotinic acid

  • CAS No. 75893-75-3

  • Cat. No. CS-W022494
  • Purity≥98%
  • MDL No.MFCD18255573

*For research and further manufacturing use only, not for direct human use.

6-Cyclopropylnicotinic acid|CS-W022494

Structure of 75893-75-3

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General Information

  • CAS No. 75893-75-3
  • Cat. No. CS-W022494
  • Purity ≥98%
  • MDL No. MFCD18255573
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₉NO₂
  • Molecular Weight 163.17
  • Synonym(s) 6-Cyclppropylpyridine-3-carboxylic acid
  • SMILES O=C(O)C1=CN=C(C2CC2)C=C1

Description

6-Cyclopropylnicotinic acid features a cyclopropyl substituent at the 6-position of the pyridine ring, imparting enhanced lipophilicity and metabolic stability. This structural motif enables efficient incorporation into bioactive molecules, particularly in medicinal chemistry campaigns targeting G protein-coupled receptors and kinase inhibitors. The carboxylic acid functionality supports direct derivatization or salt formation for improved solubility and handling.

Application

6-Cyclopropylnicotinic acid serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard amide coupling and functionalization reactions. Its cyclopropyl substituent enhances metabolic stability and modulates lipophilicity, while the carboxylic acid group facilitates direct derivatization or incorporation into pharmaceutical scaffolds. The compound exhibits good bench stability and is compatible with common purification methods, making it well-suited for iterative synthesis workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.6572
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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