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CS-W001157 4
Total: USD 88.00

2-Cyclopropylnicotinic acid

  • CAS No. 1244761-65-6

  • Cat. No. CS-0442997
  • Purity≥98%
  • MDL No.MFCD18255584

*For research and further manufacturing use only, not for direct human use.

2-Cyclopropylnicotinic acid|CS-0442997

Structure of 1244761-65-6

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General Information

  • CAS No. 1244761-65-6
  • Cat. No. CS-0442997
  • Purity ≥98%
  • MDL No. MFCD18255584
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₉NO₂
  • Molecular Weight 163.17
  • Synonym(s) None
  • SMILES C1=CC(=C(C2CC2)N=C1)C(=O)O

Description

2-Cyclopropylnicotinic acid features a cyclopropyl group at the 2-position of the nicotinic acid scaffold, imparting enhanced lipophilicity and metabolic stability. This structural motif enables direct incorporation into bioactive molecules, particularly in medicinal chemistry campaigns targeting kinase inhibitors and CNS-active compounds. The acid’s bench-stable nature facilitates handling under standard conditions.

Application

2-Cyclopropylnicotinic acid serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling and functionalization reactions. Its cyclopropyl substituent imparts enhanced metabolic stability and modulates electronic properties, while the carboxylic acid group facilitates direct amidation, esterification, or derivatization. The compound exhibits good bench stability and compatibility with diverse reaction conditions, making it well-suited for iterative synthesis workflows in API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

Quality Control

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.6572
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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