Fmoc-Phe(2-F)-OH

Name: Fmoc-Phe(2-F)-OH
Brand: ChemScene
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CAS No. 205526-26-7
Cat. No. CS-W009715
Purity≥96%
MDL No.MFCD00672552

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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General Information

CAS No. 205526-26-7
Cat. No. CS-W009715
Purity ≥96%
MDL No. MFCD00672552
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₄H₂₀FNO₄
Molecular Weight 405.42
Synonym(s) None
SMILES O=C(N[C@H](C(O)=O)CC1=CC=CC=C1F)OCC2C3=C(C4=C2C=CC=C4)C=CC=C3

Description

Fmoc-Phe(2-F)-OH features a fluorinated phenyl ring at the ortho position, enhancing electron-withdrawing character and improving metabolic stability. This derivative integrates readily into peptide chains under standard coupling conditions, offering enhanced solubility and reduced aggregation during synthesis.

Application

Fmoc-Phe(2-F)-OH serves as a valuable building block in peptide synthesis, offering enhanced metabolic stability through the ortho-fluorinated phenylalanine residue. The Fmoc group enables efficient orthogonal protection for amine-directed coupling, while the 2-fluoro substitution provides steric and electronic modulation without compromising solubility or handling. This derivative facilitates incorporation of fluorinated aromatic side chains into peptides, supporting structure-activity studies and improving proteolytic resistance in bioactive sequences.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 75.63
LogP 4.3601
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 6

Other Classifications

Bioactive Molecules Peptides

Life Science Amino Acids and their Derivatives Phenylalanine and derivatives

Building Blocks Functional Group Fmoc

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Amino Acid Derivatives

Key Words

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Fmoc-Phe(2-F)-OH

CAS No. 205526-26-7

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