Fmoc-Phe(3,4-DiF)-OH

Name: Fmoc-Phe(3,4-DiF)-OH
Brand: ChemScene
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CAS No. 198560-43-9
Cat. No. CS-W011642
Purity≥98%
MDL No.MFCD00672550

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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Structure of 198560-43-9

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General Information

CAS No. 198560-43-9
Cat. No. CS-W011642
Purity ≥98%
MDL No. MFCD00672550
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₄H₁₉F₂NO₄
Molecular Weight 423.41
Synonym(s) None
SMILES O=C(O)[C@H](CC1=CC=C(F)C(F)=C1)NC(OCC2C3=C(C4=C2C=CC=C4)C=CC=C3)=O

Description

Fmoc-Phe(3,4-DiF)-OH features a fluorinated phenylalanine residue with dual fluorines at the meta and para positions, enhancing metabolic stability and membrane permeability. This derivative integrates readily into peptide chains during solid-phase synthesis, offering improved bioavailability and resistance to enzymatic degradation in biological assays.

Application

Fmoc-Phe(3,4-DiF)-OH serves as a valuable building block in peptide synthesis, offering enhanced metabolic stability and modulated lipophilicity through its 3,4-difluorophenyl side chain. The fluorinated aromatic ring improves resistance to oxidative metabolism while maintaining favorable solubility and compatibility with standard coupling protocols. This derivative facilitates the incorporation of electron-deficient phenylalanine analogs into bioactive peptides, enabling precise tuning of conformational and pharmacokinetic properties in medicinal chemistry campaigns.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 75.63
LogP 4.4992
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 6

Other Classifications

Bioactive Molecules Peptides

Life Science Amino Acids and their Derivatives Phenylalanine and derivatives

Building Blocks Functional Group Fmoc

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Amino Acid Derivatives

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Fmoc-Phe(3,4-DiF)-OH

CAS No. 198560-43-9

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