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CS-W001157 4
Total: USD 88.00

Morpholine-3-carboxylic acid

  • CAS No. 77873-76-8

  • Cat. No. CS-W001894
  • Purity≥97%
  • MDL No.MFCD01318649

*For research and further manufacturing use only, not for direct human use.

Morpholine-3-carboxylic acid|CS-W001894

Structure of 77873-76-8

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General Information

  • CAS No. 77873-76-8
  • Cat. No. CS-W001894
  • Purity ≥97%
  • MDL No. MFCD01318649
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₉NO₃
  • Molecular Weight 131.13
  • Synonym(s) 3-Morpholinecarboxylicacid(6CI,9CI)
  • SMILES O=C(C1NCCOC1)O

Description

Morpholine-3-carboxylic acid integrates a polar, nitrogen-containing heterocycle with a carboxylic acid functional group, enabling versatile conjugation in bioactive molecule design. This scaffold offers enhanced solubility and metabolic stability, particularly valuable in medicinal chemistry applications involving peptide mimetics or kinase inhibitors.

Application

Morpholine-3-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and peptide-like scaffolds. Its amphoteric character and orthogonal reactivity support efficient derivatization under standard coupling conditions. The molecule exhibits good bench stability and facilitates purification via crystallization or ion-exchange chromatography, making it well-suited for scalable synthesis and process development workflows.

Synthesis

  • Route1
    • null|null
      77873-74-6
    • ~53%
    • In-stock
      Morpholine-3-carboxylic acid|CS-W001894
      77873-76-8

    References

    • Asher, Vikram; Becu, Christian; Anteunis, Marc J. O.; Callens, Roland Tetrahedron Letters, 1981 , vol. 22, p. 141 - 144
  • Route2
    • null|null
      102154-56-3
    • ~%
    • In-stock
      Morpholine-3-carboxylic acid|CS-W001894
      77873-76-8

    References

    • Journal of the American Chemical Society, , vol. 79, p. 5693,5696
  • Route3
    • null|null
      108595-89-7
    • null|null
      7664-41-7
    • ~%
    • In-stock
      Morpholine-3-carboxylic acid|CS-W001894
      77873-76-8
    • null|null
      10367-17-6
    • null|null
      98069-38-6

    References

    • Journal of the American Chemical Society, , vol. 79, p. 5693,5696

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   58.56
  • LogP   -0.9406
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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