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CS-W001157 4
Total: USD 88.00

4-Chloro-2-fluorophenol

  • CAS No. 348-62-9

  • Cat. No. CS-W007711
  • Purity≥97%
  • MDL No.MFCD00075030

*For research and further manufacturing use only, not for direct human use.

4-Chloro-2-fluorophenol|CS-W007711

Structure of 348-62-9

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General Information

  • CAS No. 348-62-9
  • Cat. No. CS-W007711
  • Purity ≥97%
  • MDL No. MFCD00075030
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄ClFO
  • Molecular Weight None
  • Synonym(s) 4,4,4-trifluoro-3-methylbutanoic acid
  • SMILES OC1=CC=C(Cl)C=C1F

Description

4-Chloro-2-fluorophenol features a fluorine atom at the ortho position relative to the hydroxyl group, enhancing its electron-withdrawing character and metabolic stability. This substitution pattern imparts favorable reactivity in electrophilic aromatic substitution and facilitates coupling reactions under mild conditions. The compound serves as a key intermediate in agrochemical and pharmaceutical synthesis due to its balanced polarity and structural rigidity.

Application

4-Chloro-2-fluorophenol serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the phenolic OH and ortho-position via electrophilic substitution or transition-metal-catalyzed coupling. Its halogenated aryl scaffold offers excellent compatibility with Suzuki, Stille, and Buchwald-Hartwig reactions, facilitating rapid access to complex heterocycles and bioactive intermediates. The compound exhibits robust bench stability and straightforward purification, making it ideal for high-throughput synthesis and process development.

Synthesis

  • Route1
    • null|null
      106-48-9
    • ~53%
    • In-stock
      4-Chloro-2-fluorophenol|CS-W007711
      348-62-9

    References

    • Umemoto, Teruo; Fukami, Shinji; Tomizawa, Ginjiro; Harasawa, Kikuko; Kawada, Kosuke; Tomita, Kyoichi Journal of the American Chemical Society, 1990 , vol. 112, # 23 p. 8563 - 8575
  • Route2

    References

    • Journal of the American Chemical Society, , vol. 81, p. 94,95, 97
  • Route3

    References

    • Journal of the American Chemical Society, , vol. 81, p. 94,95, 97

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   2.1847
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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