Lot numbers can be found on the outside label of a product:
(R)-1-N-Boc-beta-proline
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CAS No. 72925-16-7
- Cat. No. CS-B0422
- Purity≥97%
- MDL No.MFCD03094727
*For research and further manufacturing use only, not for direct human use.
Structure of 72925-16-7
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General Information
- CAS No. 72925-16-7
- Cat. No. CS-B0422
- Purity ≥97%
- MDL No. MFCD03094727
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₀H₁₇NO₄
- Molecular Weight 215.25
- Synonym(s) (R)-1-tert-Butoxycarbonyl-pyrrolidine-3-carboxylic acid
- SMILES O=C(OC(C)(C)C)N(CC1)C[C@@H]1C(O)=O
Description
(R)-1-N-Boc-beta-proline is a bench-stable, moisture-tolerant chiral building block featuring a protected amine and a rigid pyrrolidine ring. This configuration enables selective incorporation into peptide sequences and asymmetric synthesis, where its defined stereochemistry ensures high diastereoselectivity in coupling reactions.
Application
(R)-1-N-Boc-β-proline serves as a stable, bench-ready chiral building block for the synthesis of peptidomimetics and bioactive heterocycles. Its protected amine and carboxylic acid functionalities enable direct incorporation into SPPS workflows and facilitate efficient cyclization reactions. The Boc group ensures excellent stability during storage and handling, while enabling selective deprotection under mild acidic conditions. Functions effectively in coupling reactions with diverse nucleophiles and serves as a key scaffold in the construction of constrained β-amino acid derivatives.
Synthesis
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Route1
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In-stock
122684-33-7 - ~96%
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In-stock
72925-16-7
References
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Murphy, John A.; Tripoli, Regis; Khan, Tanweer A.; Mali, Umesh W. Organic Letters, 2005 , vol. 7, # 15 p. 3287 - 3289
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Route2
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In-stock
17012-21-4 - ~%
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In-stock
72925-16-7
References
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European Journal of Organic Chemistry, , # 4 p. 673 - 682
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Route3
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In-stock
51535-00-3 - ~%
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In-stock
72925-16-7
References
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European Journal of Organic Chemistry, , # 4 p. 673 - 682
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS09
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Signal Word : Warning
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UN#: 3077
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Class : 9
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Packing Group : Ⅲ
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Hazard Statements : H400
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 66.84
- LogP 1.328
- H_Acceptors 3
- H_Donors 1
- Rotatable_Bonds 1
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Key Words
- (R)-1-N-Boc-beta-proline sigma(R)-1-N-Boc-beta-proline manufacturer(R)-1-N-Boc-beta-proline price(R)-1-N-Boc-beta-proline structure(R)-1-N-Boc-beta-proline SDSbuy (R)-1-N-Boc-beta-proline(R)-1-N-Boc-beta-proline supplier(R)-1-N-Boc-beta-proline uses(R)-1-N-Boc-beta-proline molecular weightprice of (R)-1-N-Boc-beta-proline(R)-1-N-Boc-beta-proline chemical name formula of (R)-1-N-Boc-beta-proline