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CS-W001157 4
Total: USD 88.00

Pyrrolidine-3-carboxylic acid

  • CAS No. 59378-87-9

  • Cat. No. CS-W019683
  • Purity≥98%
  • MDL No.MFCD01318699

*For research and further manufacturing use only, not for direct human use.

Pyrrolidine-3-carboxylic acid|CS-W019683

Structure of 59378-87-9

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General Information

  • CAS No. 59378-87-9
  • Cat. No. CS-W019683
  • Purity ≥98%
  • MDL No. MFCD01318699
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₉NO₂
  • Molecular Weight None
  • Synonym(s) Pyrrolidine-3-carboxylic acid trifluoroacetate
  • SMILES O=C(C1CNCC1)O

Description

Pyrrolidine-3-carboxylic acid features a cyclic secondary amine fused to a carboxylic acid group, enabling versatile integration into bioactive scaffolds. This structural motif enhances solubility and conformational rigidity in peptide mimetics and small-molecule drug candidates.

Application

Pyrrolidine-3-carboxylic acid serves as a valuable chiral building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and peptidomimetics. Its rigid pyrrolidine ring imparts conformational control, while the carboxylic acid group facilitates straightforward derivatization via amide coupling or esterification. The molecule exhibits good bench stability and solubility in common organic solvents, supporting efficient purification and integration into multi-step synthetic sequences.

Synthesis

  • Route1

    References

    • Journal of the American Chemical Society, , vol. 134, # 15 p. 6607 - 6616
  • Route2
    • null|null
      123-75-1
    • null|null
      64-18-6
    • ~8%
    • In-stock
      Pyrrolidine-3-carboxylic acid|CS-W019683
      59378-87-9
    • Glycine, 99%|CS-1269057
      56-40-6
    • In-stock
      DL-Proline|CS-W013624
      609-36-9

    References

    • Chemistry Letters, , p. 73 - 76
  • Route3
    • null|null
      123-75-1
    • null|null
      141-53-7
    • ~0%
    • In-stock
      Pyrrolidine-3-carboxylic acid|CS-W019683
      59378-87-9
    • Glycine, 99%|CS-1269057
      56-40-6
    • In-stock
      DL-Proline|CS-W013624
      609-36-9

    References

    • Chemistry Letters, , p. 73 - 76

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H318
Precautionary Statements : P280-P305+P351+P338-P310

Quality Control

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Computational Chemistry Data

  • TPSA   49.33
  • LogP   -0.3195
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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