Lot numbers can be found on the outside label of a product:
(S)-1-Cbz-pyrrolidine-3-carboxylic acid
-
CAS No. 192214-00-9
- Cat. No. CS-W008576
- Purity≥98%
- MDL No.MFCD09608053
*For research and further manufacturing use only, not for direct human use.
Structure of 192214-00-9
Please choose your location and provide accurate information for you
| Size |
|
Price | Quantity | |||
|---|---|---|---|---|---|---|
|
* Please select Quantity before adding items. |
||||||
Recommended Products
General Information
- CAS No. 192214-00-9
- Cat. No. CS-W008576
- Purity ≥98%
- MDL No. MFCD09608053
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₃H₁₅NO₄
- Molecular Weight 249.26
- Synonym(s) (S)-1-((Benzyloxy)carbonyl)pyrrolidine-3-carboxylic acid
- SMILES O=C(OCC1=CC=CC=C1)N(CC2)C[C@H]2C(O)=O
Description
(S)-1-Cbz-pyrrolidine-3-carboxylic acid is a chiral building block featuring a pyrrolidine core with a Cbz-protected amine and a carboxylic acid at the 3-position. This configuration enables direct incorporation into peptide synthesis and medicinal chemistry campaigns, where stereochemical control is critical. The Cbz group provides stable protection under standard coupling conditions, facilitating selective functionalization and downstream deprotection without racemization.
Application
(S)-1-Cbz-pyrrolidine-3-carboxylic acid serves as a versatile chiral building block in medicinal chemistry, enabling efficient access to pyrrolidine-containing scaffolds prevalent in bioactive molecules. The Cbz group provides excellent stability and orthogonal deprotection compatibility, while the carboxylic acid facilitates coupling reactions. Its defined stereochemistry ensures high fidelity in asymmetric synthesis, making it ideal for peptide-like motifs and heterocyclic core construction.
Synthesis
-
Route1
-
501-53-1 -
193693-69-5 - ~66%
-
In-stock
192214-00-9
References
-
FOB SYNTHESIS; CHOI, Woo-Baeg; KIM, Deog-Il; GRUSZECKA-KOWALIK, Ewa; JOO, Hyung-Yeul; LIU, Shuangpei; MAO, Shuli; LI, Yongfeng Patent: WO2011/160020 A2, 2011 ; Location in patent: Page/Page column 62 ;
-
-
Route2
-
In-stock
124391-76-0 - ~89%
-
In-stock
192214-00-9
References
-
Mazzini; Lebreton; Alphand; Furstoss Journal of Organic Chemistry, 1997 , vol. 62, # 15 p. 5215 - 5218
-
-
Route3
-
865704-61-6
- ~79%
-
In-stock
192214-00-9
References
-
Stoncius, Arvydas; Nahrwold, Markus; Sewald, Norbert Synthesis, 2005 , # 11 art. no. T12704SS, p. 1829 - 1837
-
Safety Information
Download SDS|
GHS Pictogram :
|
GHS No : GHS07
|
|
Signal Word : Warning
|
UN#: N/A
|
|
Class : N/A
|
Packing Group : N/A
|
|
Hazard Statements : H302-H315-H319-H335
|
|
|
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
|
|
Quality Control
Computational Chemistry Data
- TPSA 66.84
- LogP 1.7297
- H_Acceptors 3
- H_Donors 1
- Rotatable_Bonds 3
Similar Products
Other Classifications
Recently Viewed Products
Leave US a Message
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Upload Pictures
|
|
Key Words
- (S)-1-Cbz-pyrrolidine-3-carboxylic acid sigma(S)-1-Cbz-pyrrolidine-3-carboxylic acid manufacturer(S)-1-Cbz-pyrrolidine-3-carboxylic acid price(S)-1-Cbz-pyrrolidine-3-carboxylic acid structure(S)-1-Cbz-pyrrolidine-3-carboxylic acid SDSbuy (S)-1-Cbz-pyrrolidine-3-carboxylic acid(S)-1-Cbz-pyrrolidine-3-carboxylic acid supplier(S)-1-Cbz-pyrrolidine-3-carboxylic acid uses(S)-1-Cbz-pyrrolidine-3-carboxylic acid molecular weightprice of (S)-1-Cbz-pyrrolidine-3-carboxylic acid(S)-1-Cbz-pyrrolidine-3-carboxylic acid chemical name formula of (S)-1-Cbz-pyrrolidine-3-carboxylic acid