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CS-W001157 4
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3-Fluoro-5-iodobenzoic acid

  • CAS No. 723294-74-4

  • Cat. No. CS-0028256
  • Molecule weight266.01
  • Purity≥97%
  • MDL No.MFCD04116467

*For research and further manufacturing use only, not for direct human use.

3-Fluoro-5-iodobenzoic acid|CS-0028256

Structure of 723294-74-4

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General Information

  • CAS No. 723294-74-4
  • Cat. No. CS-0028256
  • Purity ≥97%
  • MDL No. MFCD04116467
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₄FIO₂
  • Molecular Weight 266.01
  • Synonym(s) None
  • SMILES OC(C1=CC(F)=CC(I)=C1)=O

Description

3-Fluoro-5-iodobenzoic acid features a fluorinated benzene ring bearing iodine and carboxylic acid groups at meta positions, enabling selective cross-coupling reactions. The electron-withdrawing fluorine enhances reactivity in palladium-catalyzed transformations, while the iodide serves as a high-efficiency coupling handle. This compound offers excellent stability under standard bench conditions and integrates readily into complex molecular architectures.

Application

3-Fluoro-5-iodobenzoic acid serves as a versatile building block for palladium-catalyzed cross-coupling reactions, enabling efficient access to substituted biaryls and heterocycles. The ortho-fluoro and meta-iodo groups provide orthogonal reactivity, facilitating sequential functionalization. Its bench-stable carboxylic acid functionality supports direct derivatization or use in amide coupling protocols, making it well-suited for medicinal chemistry and process development workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   2.1285
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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