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Total: USD 88.00

3-Cyclopropyl-1-methyl-1H-pyrazol-5-amine

  • CAS No. 118430-74-3

  • Cat. No. CS-0098976
  • Purity≥98%
  • MDL No.MFCD00067984

*For research and further manufacturing use only, not for direct human use.

3-Cyclopropyl-1-methyl-1H-pyrazol-5-amine|CS-0098976

Structure of 118430-74-3

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General Information

  • CAS No. 118430-74-3
  • Cat. No. CS-0098976
  • Purity ≥98%
  • MDL No. MFCD00067984
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₁N₃
  • Molecular Weight 137.18
  • Synonym(s) 5-CYCLOPROPYL-2-METHYL-2 H-PYRAZOL-3-YLAMINE
  • SMILES NC1=CC(C2CC2)=NN1C

Description

3-Cyclopropyl-1-methyl-1H-pyrazol-5-amine features a sterically hindered pyrazole core with a cyclopropyl group at the 3-position and a methyl substituent on the nitrogen, enhancing metabolic stability. The electron-rich aromatic system supports efficient coupling reactions, enabling rapid integration into bioactive scaffolds for medicinal chemistry applications.

Application

3-Cyclopropyl-1-methyl-1H-pyrazol-5-amine serves as a versatile heterocyclic building block in medicinal chemistry, enabling the construction of bioactive scaffolds through standard coupling and functionalization reactions. Its cyclopropyl and methyl substituents enhance metabolic stability and modulate lipophilicity, while the primary amine facilitates conjugation and derivatization. The compound exhibits good bench stability and is compatible with common purification methods, making it well-suited for iterative synthesis workflows in API development.

Synthesis

  • Route1
    • In-stock
      3-Cyclopropyl-3-oxopropanenitrile|CS-0006959
      118431-88-2
    • null|null
      60-34-4
    • ~52%
    • In-stock
      3-Cyclopropyl-1-methyl-1H-pyrazol-5-amine|CS-0098976
      118430-74-3

    References

    • Chemical and Pharmaceutical Bulletin, , vol. 35, # 8 p. 3235 - 3252

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   43.84
  • LogP   0.8797
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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