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tert-Butyl 1,2-dihydrospiro[indole-3,4'-piperidine]-1-carboxylate

  • CAS No. 676607-31-1

  • Cat. No. CS-0048497
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 1,2-dihydrospiro[indole-3,4'-piperidine]-1-carboxylate|CS-0048497

Structure of 676607-31-1

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General Information

  • CAS No. 676607-31-1
  • Cat. No. CS-0048497
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₇H₂₄N₂O₂
  • Molecular Weight 288.38
  • Synonym(s) Tert-butyl spiro[indoline-3,4'-piperidine]-1-carboxylate
  • SMILES CC(C)(C)OC(=O)N1CC2(CCNCC2)C2=CC=CC=C12

Synthesis

  • Route1
    • tert-Butyl 1'-benzylspiro[indoline-3,4'-piperidine]-1-carboxylate|CS-0673903
      867009-74-3
    • ~79%
    • tert-Butyl 1,2-dihydrospiro[indole-3,4'-piperidine]-1-carboxylate|CS-0048497
      676607-31-1

    References

    • JANSSEN PHARMACEUTICA N.V. Patent: WO2005/97794 A1, 2005 ; Location in patent: Page/Page column 43 ; WO 2005/097794 A1
  • Route2
    • null|null
      676607-30-0
    • ~%
    • tert-Butyl 1,2-dihydrospiro[indole-3,4'-piperidine]-1-carboxylate|CS-0048497
      676607-31-1

    References

    • WO2012/177782 A1, ; Page/Page column 108 ; WO 2012/177782 A1
  • Route3

    References

    • WO2012/177782 A1, ; WO 2012/177782 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   41.57
  • LogP   3.0629
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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