Spiro[indoline-3,4'-piperidin]-2-one

Name: Spiro[indoline-3,4'-piperidin]-2-one
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 252882-61-4
Cat. No. CS-W006015
Purity≥97%
MDL No.MFCD12198581

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Spiro[indoline-3,4'-piperidin]-2-one|CS-W006015

Structure of 252882-61-4

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General Information

CAS No. 252882-61-4
Cat. No. CS-W006015
Purity ≥97%
MDL No. MFCD12198581
Storage RT, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₂H₁₄N₂O
Molecular Weight 202.25
Synonym(s) Spiro[3H-indole-3,4'-piperidin]-2(1H)-one
SMILES N1CCC3(CC1)C2=CC=CC=C2NC3=O

Description

Spiro[indoline-3,4'-piperidin]-2-one delivers a rigid, three-dimensional scaffold ideal for medicinal chemistry. This spirocyclic core integrates a nitrogen-rich piperidine moiety with an indoline framework, enhancing target engagement and metabolic stability. The ketone functionality at the spiro junction enables direct derivatization, supporting rapid library expansion in drug discovery campaigns.

Application

Spiro[indoline-3,4'-piperidin]-2-one serves as a versatile scaffold in medicinal chemistry, enabling efficient construction of complex alkaloid-like architectures. Its spirocyclic core provides rigidity and defined stereochemistry, while the ketone functionality supports selective reductions, nucleophilic additions, and further functionalization. The molecule exhibits good bench stability and compatibility with standard synthetic transformations, facilitating its use in lead optimization campaigns and heterocycle diversification.

Synthesis

Route1
- 1086063-19-5
- ~90%
- In-stock
  
  252882-61-4
References
- KOWA CO., LTD. Patent: US2008/306102 A1, 2008 ; Location in patent: Page/Page column 12 ; US 20080306102 A1
Route2
- In-stock
  
  252882-60-3
- ~%
- In-stock
  
  252882-61-4
References
- US6172076 B2, ; US 6172076 B1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 41.13
LogP 1.2599
H_Acceptors 2
H_Donors 2
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Aromatic heterocycle compounds Indolin compounds

Key Words

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Spiro[indoline-3,4'-piperidin]-2-one

CAS No. 252882-61-4

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