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CS-W001157 4
Total: USD 88.00

3-Methylmorpholine

  • CAS No. 42185-06-8

  • Cat. No. CS-W009058
  • Purity≥95%
  • MDL No.MFCD09054773

*For research and further manufacturing use only, not for direct human use.

3-Methylmorpholine|CS-W009058

Structure of 42185-06-8

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General Information

  • CAS No. 42185-06-8
  • Cat. No. CS-W009058
  • Purity ≥95%
  • MDL No. MFCD09054773
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₁NO
  • Molecular Weight 101.15
  • Synonym(s) 5-Methylmorpholine; NSC 157717; Morpholine, 3-methyl-
  • SMILES CC1NCCOC1

Description

3-Methylmorpholine is a bench-stable, nitrogen-containing heterocycle featuring a methyl-substituted morpholine core. This sterically hindered amine exhibits enhanced nucleophilicity and reduced basicity compared to morpholine, enabling selective reactivity in synthetic transformations. It serves as a valuable catalyst and auxiliary in organic synthesis, particularly in reactions requiring moderate basicity and improved solubility in polar aprotic media.

Application

3-Methylmorpholine serves as a versatile tertiary amine base and nucleophilic catalyst in synthetic organic chemistry. It facilitates efficient deprotonation, promotes nucleophilic substitution reactions, and enhances selectivity in acyl transfer processes. Its moderate basicity and low nucleophilicity toward electrophiles make it well-suited for bench-scale applications requiring clean reaction profiles and ease of purification.

Synthesis

  • Route1
    • null|null
      1268866-46-1
    • ~64%
    • In-stock
      3-Methylmorpholine|CS-W009058
      42185-06-8

    References

    • BIOENERGENIX; MCCALL, John, M.; MCKEARN, John; ROMERO, Donnal, L.; CLAIR, Michael Patent: WO2011/28947 A2, 2011 ; Location in patent: Page/Page column 154; 157 ; WO 2011/028947 A1
  • Route2
    • null|null
      1268866-42-7
    • ~%
    • In-stock
      3-Methylmorpholine|CS-W009058
      42185-06-8

    References

    • BIOENERGENIX; MCCALL, John, M.; MCKEARN, John; ROMERO, Donnal, L.; CLAIR, Michael Patent: WO2011/28947 A2, 2011 ; WO 2011/028947 A1
  • Route3
    • null|null
      1268866-44-9
    • ~%
    • In-stock
      3-Methylmorpholine|CS-W009058
      42185-06-8

    References

    • BIOENERGENIX; MCCALL, John, M.; MCKEARN, John; ROMERO, Donnal, L.; CLAIR, Michael Patent: WO2011/28947 A2, 2011 ; WO 2011/028947 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS05
Signal Word : Danger
UN#: 2734
Class : 8,3
Packing Group : Ⅱ
Hazard Statements : H226-H314
Precautionary Statements : P210-P233-P240-P241-P242-P243-P260-P264-P280-P301+P330+P331-P304+P340-P363-P370+P378-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   21.26
  • LogP   -0.0053
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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