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CS-W001157 4
Total: USD 88.00

(R)-3-Methylmorpholine hydrochloride

  • CAS No. 953780-78-4

  • Cat. No. CS-W020732
  • Purity≥95%
  • MDL No.MFCD18382515

*For research and further manufacturing use only, not for direct human use.

(R)-3-Methylmorpholine hydrochloride|CS-W020732

Structure of 953780-78-4

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General Information

  • CAS No. 953780-78-4
  • Cat. No. CS-W020732
  • Purity ≥95%
  • MDL No. MFCD18382515
  • Storage Store at room temperature, keep dry and cool
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₂ClNO
  • Molecular Weight 137.61
  • Synonym(s) (3R)-3-methylmorpholine,hydrochloride
  • SMILES C[C@H]1NCCOC1.[H]Cl

Description

(R)-3-Methylmorpholine hydrochloride is a chiral, bench-stable amine salt featuring a stereodefined tertiary nitrogen within a morpholine ring. This configuration enables selective incorporation into asymmetric synthesis and catalytic systems. The hydrochloride form enhances solubility in polar solvents and simplifies handling in aqueous or protic reaction media.

Application

(R)-3-Methylmorpholine hydrochloride serves as a chiral auxiliary and versatile building block in asymmetric synthesis, enabling stereoselective transformations through its well-defined stereochemistry. The hydrochloride salt enhances stability and solubility, facilitating handling and purification in standard organic workflows. It functions effectively in nucleophilic substitutions, catalytic reductions, and heterocycle formation, offering reliable performance in medicinal chemistry and process development applications.

Synthesis

  • Route1
    • (R)-4-benzyl-3-methylmorpholine|CS-0466332
      74571-98-5
    • ~%
    • In-stock
      (R)-3-Methylmorpholine hydrochloride|CS-W020732
      953780-78-4

    References

    • WO2010/59658 A1, ; Page/Page column 182-183 ; WO 2010/059658 A1
  • Route2
    • null|null
      954133-47-2
    • ~73%
    • In-stock
      (R)-3-Methylmorpholine hydrochloride|CS-W020732
      953780-78-4

    References

    • MITSUBISHI PHARMA CORPORATION; SANOFI-AVENTIS Patent: WO2007/119463 A1, 2007 ; Location in patent: Page/Page column 197; 198 ; WO 2007/119463 A1
  • Route3
    • null|null
      120800-86-4
    • ~%
    • In-stock
      (R)-3-Methylmorpholine hydrochloride|CS-W020732
      953780-78-4

    References

    • Journal of Medicinal Chemistry, , vol. 54, # 6 p. 1871 - 1895

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   21.26
  • LogP   0.4165
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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