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CS-W001157 4
Total: USD 88.00

(R)-3-Methylmorpholine

  • CAS No. 74572-04-6

  • Cat. No. CS-D1634
  • Purity≥98%
  • MDL No.MFCD10698482

*For research and further manufacturing use only, not for direct human use.

(R)-3-Methylmorpholine|CS-D1634

Structure of 74572-04-6

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General Information

  • CAS No. 74572-04-6
  • Cat. No. CS-D1634
  • Purity ≥98%
  • MDL No. MFCD10698482
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₁NO
  • Molecular Weight 101.15
  • Synonym(s) (3R)-3-Methylmorpholine; (R)-3-Methylmorpholine; 3R-3-Methylmorpholine
  • SMILES C[C@H]1NCCOC1

Description

(R)-3-Methylmorpholine is a chiral heterocyclic amine featuring a stereogenic center at the 3-position, offering enhanced selectivity in asymmetric synthesis. This bench-stable, moisture-tolerant nitrogen heterocycle functions as a valuable auxiliary in catalytic transformations and molecular scaffold design.

Application

(R)-3-Methylmorpholine serves as a valuable chiral building block in synthetic organic chemistry, offering a stable, bench-friendly heterocyclic scaffold with defined stereochemistry. It functions as a versatile nitrogen source in catalytic asymmetric synthesis and enables efficient construction of bioactive alkaloid frameworks. The molecule exhibits excellent functional group tolerance and facilitates stereoselective transformations under mild reaction conditions, making it well-suited for medicinal chemistry and process development workflows.

Synthesis

  • Route1
    • (R)-4-benzyl-3-methylmorpholine|CS-0466332
      74571-98-5
    • ~%
    • In-stock
      (R)-3-Methylmorpholine|CS-D1634
      74572-04-6

    References

    • Tetrahedron, , vol. 36, p. 409 - 415
  • Route2

    References

    • EP1785418 A1, ; Page/Page column 149 ;
  • Route3
    • null|null
      954133-47-2
    • ~81%
    • In-stock
      (R)-3-Methylmorpholine|CS-D1634
      74572-04-6

    References

    • MEDIVIR AB; AYESA, Susana; BELDA, Oscar; BJÖRKLUND, Catarina; NILSSON, Magnus; RUSSO, Francesco; SAHLBERG, Christer; WIKTELIUS, Daniel Patent: WO2013/95275 A1, 2013 ; Location in patent: Page/Page column 39; 40 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS05
Signal Word : Danger
UN#: 2734
Class : 8,3
Packing Group : Ⅱ
Hazard Statements : H226-H314
Precautionary Statements : P210-P233-P240-P241-P242-P243-P260-P264-P280-P301+P330+P331-P304+P340-P363-P370+P378-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   21.26
  • LogP   -0.0053
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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