Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

tert-Butyl 1,2-dihydrospiro[indole-3,4'-piperidine]-1'-carboxylate

  • CAS No. 180465-84-3

  • Cat. No. CS-0038517
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 1,2-dihydrospiro[indole-3,4'-piperidine]-1'-carboxylate|CS-0038517

Structure of 180465-84-3

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 180465-84-3
  • Cat. No. CS-0038517
  • Purity ≥96%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₇H₂₄N₂O₂
  • Molecular Weight 288.39
  • Synonym(s) Tert-butyl spiro[indoline-3,4'-piperidine]-1'-carboxylate
  • SMILES CC(C)(C)OC(=O)N1CCC2(CC1)CNC3=C2C=CC=C3

Description

tert-Butyl 1,2-dihydrospiro[indole-3,4'-piperidine]-1'-carboxylate features a spirocyclic indole-piperidine architecture with a bench-stable tert-butyl carbamate protecting group. This scaffold integrates a rigid, three-dimensional core ideal for accessing complex alkaloid-like structures in medicinal chemistry and natural product synthesis.

Application

tert-Butyl 1,2-dihydrospiro[indole-3,4'-piperidine]-1'-carboxylate serves as a versatile spirocyclic scaffold for medicinal chemistry campaigns, enabling efficient access to indole-piperidine architectures. Its tert-butyl carbamate group offers excellent bench stability and facilitates straightforward deprotection under mild acidic conditions. The molecule exhibits robust functional group tolerance and functions effectively in standard coupling and cyclization protocols, supporting rapid diversification in lead optimization workflows.

Synthesis

  • Route1
    • In-stock
      Di-tert-butyl dicarbonate|CS-0017817
      24424-99-5
    • Spiro[indoline-3,4'-piperidine]|CS-0089860
      171-75-5
    • ~90%
    • In-stock
      tert-Butyl 1,2-dihydrospiro[indole-3,4'-piperidine]-1'-carboxylate|CS-0038517
      180465-84-3

    References

    • Tetrahedron, , vol. 60, # 22 p. 4875 - 4878
  • Route2
    • 4-(2-Fluorophenyl)piperidine-4-carbonitrile|CS-0450151
      252002-43-0
    • ~%
    • In-stock
      tert-Butyl 1,2-dihydrospiro[indole-3,4'-piperidine]-1'-carboxylate|CS-0038517
      180465-84-3

    References

    • Tetrahedron, , vol. 60, # 22 p. 4875 - 4878
  • Route3
    • Tert-butyl 4-cyano-4-(2-fluorophenyl)piperidine-1-carboxylate|CS-0455284
      726198-18-1
    • ~%
    • In-stock
      tert-Butyl 1,2-dihydrospiro[indole-3,4'-piperidine]-1'-carboxylate|CS-0038517
      180465-84-3

    References

    • Tetrahedron, , vol. 60, # 22 p. 4875 - 4878

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   41.57
  • LogP   3.3808
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 180465-84-3 sigma180465-84-3 manufacturer180465-84-3 price180465-84-3 structure180465-84-3 SDSbuy 180465-84-3180465-84-3 supplier180465-84-3 uses180465-84-3 molecular weightprice of 180465-84-3180465-84-3 chemical name formula of 180465-84-3
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label