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CS-W001157 4
Total: USD 88.00

Benzyl 1,2-dihydrospiro[indole-3,4'-piperidine]-1'-carboxylate

  • CAS No. 167484-18-6

  • Cat. No. CS-0049879
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Benzyl 1,2-dihydrospiro[indole-3,4'-piperidine]-1'-carboxylate|CS-0049879

Structure of 167484-18-6

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General Information

  • CAS No. 167484-18-6
  • Cat. No. CS-0049879
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₀H₂₂N₂O₂
  • Molecular Weight 322.40
  • Synonym(s) Spiro[indoline-3,4'-piperidine]-1'-carboxylic Acid Benzyl Ester
  • SMILES O=C(OCC1=CC=CC=C1)N1CCC2(CNC3=CC=CC=C23)CC1

Synthesis

  • Route1
    • In-stock
      4-Formyl-N-Cbz-piperidine|CS-W002758
      138163-08-3
    • null|null
      100-63-0
    • ~81%
    • In-stock
      Benzyl 1,2-dihydrospiro[indole-3,4'-piperidine]-1'-carboxylate|CS-0049879
      167484-18-6

    References

    • ELI LILLY AND COMPANY; HAMDOUCHI, Chafiq; LINESWALA, Jayana, Pankaj; MAITI, Pranab Patent: WO2011/66183 A1, 2011 ; Location in patent: Page/Page column 11 ; WO 2011/066183 A1
  • Route2
    • In-stock
      N-(Benzyloxycarbonyloxy)succinimide|CS-D0812
      13139-17-8
    • Spiro[indoline-3,4'-piperidine]|CS-0089860
      171-75-5
    • ~86%
    • In-stock
      Benzyl 1,2-dihydrospiro[indole-3,4'-piperidine]-1'-carboxylate|CS-0049879
      167484-18-6

    References

    • Xie, Jian-Shu; Huang, Charles Q.; Fang, Yan-Yan; Zhu, Yun-Fei Tetrahedron, 2004 , vol. 60, # 22 p. 4875 - 4878
  • Route3

    References

    • WO2012/177782 A1, ; Page/Page column 106-107 ; WO 2012/177782 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   41.57
  • LogP   3.7825
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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