tert-Butyl 6-bromo-2-oxo-1,2-dihydrospiro[indole-3,4'-piperidine]-1'-carboxylate

Name: tert-Butyl 6-bromo-2-oxo-1,2-dihydrospiro[indole-3,4'-piperidine]-1'-carboxylate
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1160247-29-9
Cat. No. CS-0036789
Purity≥97%
MDL No.None

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 6-bromo-2-oxo-1,2-dihydrospiro[indole-3,4'-piperidine]-1'-carboxylate|CS-0036789

Structure of 1160247-29-9

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 1160247-29-9
Cat. No. CS-0036789
Purity ≥97%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₇H₂₁BrN₂O₃
Molecular Weight 381.26
Synonym(s) tert-Butyl 6-broMo-2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate
SMILES CC(C)(C)OC(=O)N1CCC2(CC1)C3=CC=C(C=C3NC2=O)Br

Description

tert-Butyl 6-bromo-2-oxo-1,2-dihydrospiro[indole-3,4'-piperidine]-1'-carboxylate features a spirocyclic scaffold integrating an indole and piperidine ring system, with a brominated C6 position enabling downstream functionalization. The tert-butyl ester group provides stability and ease of manipulation under standard conditions. This compound serves as a key intermediate in the synthesis of complex alkaloid architectures and bioactive molecules.

Application

tert-Butyl 6-bromo-2-oxo-1,2-dihydrospiro[indole-3,4'-piperidine]-1'-carboxylate serves as a versatile spirocyclic scaffold for medicinal chemistry campaigns, enabling efficient access to indole-piperidine hybrids. The bromine atom facilitates late-stage functionalization via palladium-catalyzed cross-coupling, while the protected piperidine nitrogen and oxo group offer orthogonal reactivity. Bench-stable and amenable to purification by flash chromatography, it functions as a key building block in the synthesis of bioactive heterocycles and targeted API candidates.

Synthesis

Route1
- In-stock
  
  99365-40-9
- 118753-70-1
- ~22%
- In-stock
  
  1160247-29-9
References
- Laboratorios Almirall, S.A. Patent: EP2108641 A1, 2009 ; Location in patent: Page/Page column 34 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 58.64
LogP 3.6699
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Boc

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Aromatic heterocycle compounds Indolin compounds

Key Words

1160247-29-9 sigma1160247-29-9 manufacturer1160247-29-9 price1160247-29-9 structure1160247-29-9 SDSbuy 1160247-29-91160247-29-9 supplier1160247-29-9 uses1160247-29-9 molecular weightprice of 1160247-29-91160247-29-9 chemical name formula of 1160247-29-9

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

tert-Butyl 6-bromo-2-oxo-1,2-dihydrospiro[indole-3,4'-piperidine]-1'-carboxylate

CAS No. 1160247-29-9

Recommended Products