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CS-W001157 4
Total: USD 88.00

2-Methoxy-3-methylbenzaldehyde

  • CAS No. 67639-61-6

  • Cat. No. CS-0131314
  • Molecule weight150.17
  • Purity≥98%
  • MDL No.MFCD07783657

*For research and further manufacturing use only, not for direct human use.

2-Methoxy-3-methylbenzaldehyde|CS-0131314

Structure of 67639-61-6

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General Information

  • CAS No. 67639-61-6
  • Cat. No. CS-0131314
  • Purity ≥98%
  • MDL No. MFCD07783657
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₀O₂
  • Molecular Weight 150.17
  • Synonym(s) None
  • SMILES O=CC1=CC=CC(C)=C1OC

Description

2-Methoxy-3-methylbenzaldehyde features a benzaldehyde core with ortho-methoxy and methyl substituents, delivering enhanced electron density at the aromatic ring. This configuration supports efficient electrophilic functionalization and facilitates coupling reactions in complex molecule synthesis. The aldehyde group enables direct incorporation into imine-based architectures and serves as a key handle for reductive amination protocols.

Application

2-Methoxy-3-methylbenzaldehyde serves as a versatile building block in medicinal chemistry and agrochemical synthesis, offering a well-defined ortho-substituted aromatic aldehyde scaffold. Its methoxy and methyl groups provide predictable electronic and steric modulation, enabling reliable coupling reactions, reductive aminations, and heterocycle formation. The compound exhibits excellent bench stability and facilitates straightforward purification via crystallization or column chromatography, making it ideal for iterative synthetic workflows.

Synthesis

  • Route1
    • In-stock
      2-Hydroxy-3-methylbenzaldehyde|CS-W007934
      824-42-0
    • null|null
      74-88-4
    • ~99%
    • In-stock
      2-Methoxy-3-methylbenzaldehyde|CS-0131314
      67639-61-6

    References

    • AVENTIS PHARMACEUTICALS INC. Patent: WO2005/111025 A1, 2005 ; Location in patent: Page/Page column 89-90 ; WO 2005/111025 A1
  • Route2

    References

    • Cannon; Koble; Long; Verimer Journal of Medicinal Chemistry, 1980 , vol. 23, # 7 p. 750 - 754
  • Route3
    • Methyl 2-methoxy-3-methylbenzoate|CS-0208771
      52239-62-0
    • ~%
    • In-stock
      2-Methoxy-3-methylbenzaldehyde|CS-0131314
      67639-61-6

    References

    • Cannon; Koble; Long; Verimer Journal of Medicinal Chemistry, 1980 , vol. 23, # 7 p. 750 - 754

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   26.3
  • LogP   1.81612
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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