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2-Methoxyquinoline-3-carbaldehyde

  • CAS No. 139549-06-7

  • Cat. No. CS-0074789
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Methoxyquinoline-3-carbaldehyde|CS-0074789

Structure of 139549-06-7

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General Information

  • CAS No. 139549-06-7
  • Cat. No. CS-0074789
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₉NO₂
  • Molecular Weight 187.19
  • Synonym(s) 2-METHOXY-QUINOLINE-3-CARBALDEHYDE
  • SMILES O=CC1=CC2=CC=CC=C2N=C1OC

Description

2-Methoxyquinoline-3-carbaldehyde features a quinoline scaffold with a methoxy group at the 2-position and a formyl group at the 3-position, enabling direct integration into heterocyclic architectures. This electron-deficient aldehyde facilitates efficient coupling reactions and serves as a key building block in medicinal chemistry and materials science applications.

Application

2-Methoxyquinoline-3-carbaldehyde serves as a versatile building block in medicinal chemistry, enabling efficient access to quinoline-based scaffolds through standard coupling and functionalization reactions. Its aldehyde functionality facilitates reductive amination, Wittig olefination, and nucleophilic addition, while the methoxy group enhances solubility and modulates electronic properties. The compound exhibits good bench stability and is amenable to purification via flash chromatography, supporting its use in multi-step syntheses and high-throughput screening campaigns.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P330-P362-P405-P501

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Computational Chemistry Data

  • TPSA   39.19
  • LogP   2.0559
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

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