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CS-W001157 4
Total: USD 88.00

2-Methoxy-5-methylbenzaldehyde

  • CAS No. 7083-19-4

  • Cat. No. CS-M1298
  • Purity≥98%
  • MDL No.MFCD02261770

*For research and further manufacturing use only, not for direct human use.

2-Methoxy-5-methylbenzaldehyde|CS-M1298

Structure of 7083-19-4

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General Information

  • CAS No. 7083-19-4
  • Cat. No. CS-M1298
  • Purity ≥98%
  • MDL No. MFCD02261770
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₀O₂
  • Molecular Weight 150.17
  • Synonym(s) 5-Methyl-2-methoxybenzaldehyde
  • SMILES O=CC1=C(OC)C=CC(C)=C1

Description

2-Methoxy-5-methylbenzaldehyde features a benzaldehyde core with strategically positioned methoxy and methyl groups, delivering enhanced electron density and steric profile. This combination enables efficient coupling in transition metal-catalyzed reactions and supports stable incorporation into complex molecular architectures under standard conditions.

Application

2-Methoxy-5-methylbenzaldehyde serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient access to substituted benzodihydrofurans and heterocyclic scaffolds. Its ortho-methoxy and meta-methyl groups provide predictable regioselectivity in electrophilic aromatic substitution and facilitate downstream functionalization via alkylation, coupling, or oxidation reactions. The aldehyde functionality offers high reactivity in condensation processes, including Mannich and Wittig reactions, with excellent bench stability and straightforward purification by column chromatography.

Synthesis

  • Route1
    • In-stock
      NSC 97517|CS-W008835
      613-84-3
    • null|null
      74-88-4
    • ~99%
    • In-stock
      2-Methoxy-5-methylbenzaldehyde|CS-M1298
      7083-19-4

    References

    • Roesner, Stefan; Aggarwal, Varinder K. Canadian Journal of Chemistry, 2012 , vol. 90, # 11 p. 965 - 974
  • Route2
    • In-stock
      4-Methylanisole|CS-W013551
      104-93-8
    • null|null
      4885-02-3
    • ~61%
    • In-stock
      2-Methoxy-5-methylbenzaldehyde|CS-M1298
      7083-19-4

    References

    • Ohsawa, Kosuke; Yoshida, Masahito; Doi, Takayuki Journal of Organic Chemistry, 2013 , vol. 78, # 7 p. 3438 - 3444
  • Route3

    References

    • Journal of the American Chemical Society, , vol. 46, p. 1521

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.3
  • LogP   1.81612
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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