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(2-Methoxy-3-methylphenyl)methanol

  • CAS No. 74090-48-5

  • Cat. No. CS-0181746
  • Molecule weight152.19
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(2-Methoxy-3-methylphenyl)methanol|CS-0181746

Structure of 74090-48-5

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General Information

  • CAS No. 74090-48-5
  • Cat. No. CS-0181746
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₂O₂
  • Molecular Weight 152.19
  • Synonym(s) 2-Methoxy-3-methylbenzyl alcohol
  • SMILES OCC1=CC=CC(C)=C1OC

Description

This bench-stable phenolic alcohol features a methoxy group at the ortho position and a methyl substituent at the meta position, enhancing electronic delocalization and steric protection. The benzylic hydroxyl enables straightforward derivatization, while the substituted aromatic core supports selective functionalization in synthesis.

Application

(2-Methoxy-3-methylphenyl)methanol serves as a versatile arylmethanol building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its ortho-methoxy and methyl substituents provide favorable electronic and steric profiles, enabling selective functionalization in palladium-catalyzed cross-coupling reactions. The benzylic alcohol functionality facilitates oxidation to aldehydes or carboxylic acids, and the molecule exhibits good bench stability and ease of purification, making it well-suited for iterative synthetic sequences in medicinal chemistry and process development workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

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Computational Chemistry Data

  • TPSA   29.46
  • LogP   1.49592
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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