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Ethyl 3-chloropyrazine-2-carboxylate

  • CAS No. 655247-45-3

  • Cat. No. CS-0042811
  • Purity≥97%
  • MDL No.MFCD07371661

*For research and further manufacturing use only, not for direct human use.

Ethyl 3-chloropyrazine-2-carboxylate|CS-0042811

Structure of 655247-45-3

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General Information

  • CAS No. 655247-45-3
  • Cat. No. CS-0042811
  • Purity ≥97%
  • MDL No. MFCD07371661
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇ClN₂O₂
  • Molecular Weight 186.60
  • Synonym(s) ETHYL 3-CHLORO-PYRAZINE-2-CARBOXYLATE
  • SMILES O=C(C1=NC=CN=C1Cl)OCC

Description

Ethyl 3-chloropyrazine-2-carboxylate features a chlorinated pyrazine core enabling direct functionalization in heterocyclic synthesis. This bench-stable, moisture-tolerant reagent integrates readily into cross-coupling and nucleophilic substitution workflows, delivering access to complex nitrogen-rich scaffolds with high regioselectivity.

Application

Ethyl 3-chloropyrazine-2-carboxylate serves as a versatile building block in heterocyclic synthesis, enabling efficient access to pyrazine-based scaffolds through nucleophilic substitution and transition-metal-catalyzed coupling reactions. The chloro group at the 3-position exhibits high reactivity toward amines, thiols, and organometallic reagents, facilitating rapid diversification. Its bench-stable nature and compatibility with common reaction conditions make it well-suited for medicinal chemistry campaigns and process development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   52.08
  • LogP   1.3067
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   2

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